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2023, Vol. 3, Issue 1, Part B

Comparative study of physicochemical properties and biological activities through cheminformatics for two auxinic herbicides 2,4,5-T and Triclopyr with same substitutive pattern of chlorines on aromatic system


Author(s): Bhupinder Mehta

Abstract: Herbicides are of immense importance in agricultural practices. Herbicides are phytotoxic chemicals used for control of unwanted plants and weeds. Herbicides differ in their chemical structure and that results in distinct difference in their properties, toxicity, mechanism of action and use. The 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) and 3,5,6-trichloro-2-pyridinyloxyacetic acid (Triclopyr) are synthetic auxinic herbicides, that belong to aryloxy acetic acid class of herbicides. They produce their herbicidal effects by over stimulating plant growth. These are effectively used against broadleaf weeds. These two herbicides are structurally similar, having similar substitutive pattern for three chlorines present on aromatic ring system, except that in case of 2,4,5-T the aromatic system is phenyl ring whereas the triclopyr has heterocyclic aromatic system as pyridyl ring. It was of interest to study how the difference in aromatic system affects the physicochemical properties and biological activities of the two herbicides. Their physicochemical parameter, pharmacokinetics and biological activities for possible adverse and toxic effects are compared through computational approach. Biological activities for possible adverse and toxic effects were predicted using PASS (Prediction of Activity Spectra for Substances) software tool.

Pages: 159-162 | Views: 220 | Downloads: 87

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South Asian Journal of Agricultural Sciences
How to cite this article:
Bhupinder Mehta. Comparative study of physicochemical properties and biological activities through cheminformatics for two auxinic herbicides 2,4,5-T and Triclopyr with same substitutive pattern of chlorines on aromatic system. South Asian J Agric Sci 2023;3(1):159-162.
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