Author(s): Bhupinder Mehta and Manju Mehta

Abstract: Organophosphate insecticides are widely used for crop protection. Monocrotophos and Dicrotophos are systemic organophosphate insecticides and are vinyl phosphates derivatives. Monocrotophos is used to control insect pests like aphids, caterpillars, common mites, spiders, ticks. Dicrotophos is used to control boring, chewing, sucking pests, aphids, leafhopper. These are low cost, highly effective insecticides and are widely used in agriculture. The excessive and uncontrolled use of these insecticides in agriculture has been a threat to environment and living organisms. Both Monocrotophos and dicrotophos inhibit acetylcholinesterase enzyme. The inhibition of Acetylcholinesterase results in the accumulation of acetylcholine, which can cause a range of symptoms, including muscle twitching, weakness, and paralysis. Due to their high toxicity monocrotophos is completely banned worldwide and dicrotophos has been added to the pesticide list of refused registration. These two insecticides are structurally similar, except that monocrotophos is N-methyl substituted amide whereas dicrotophos is N, N-dimethyl substituted amide. The presence of an additional methyl group on nitrogen in dicrotophos compared to monocrotophos prompted us for relative study of their physicochemical properties namely solubility and lipophilicity across a range of pH using ChemAxon chemicalize (licenced version) online web server. The biological activities for possible adverse and toxic effects were also studied using Prediction of Activity Spectra for Substances (PASS) online web server.

DOI: 10.22271/27889289.2024.v4.i1a.112

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